Delivering on the promise of RNA therapeutics

SiSaf is an RNA delivery and therapeutics company.

Our proprietary Bio-Courier® technology addresses the limitations of other RNA delivery technologies through the hybridization of organic materials with inorganic bioabsorbable silicon.

SiSaf is an RNA delivery and therapeutics company.

Our proprietary Bio-Courier® technology addresses the limitations of other RNA delivery technologies through the hybridization of organic materials with inorganic bioabsorbable silicon.

Our Science

SiSaf’s Bio-Courier technology combines a proprietary bioabsorbable silicon matrix with surface lipids and amino acids, a structure that addresses several of the major limitations and concerns associated with lipid nanoparticles to deliver RNA therapeutics.

Silicon’s durable electrostatic potential helps bind and stabilise RNA reducing the need for potentially toxic cationic lipids and averting the risk of premature detachment of RNA.

The high structural integrity of the silicon metalloid matrix prevents collapse on freeze drying and reduces the need for PEGylation, a key step to avoid the need for ultra-cold supply chain storage.

Our Pipeline

SiSaf is developing a growing pipeline of RNA therapeutics for rare diseases. These therapeutics utilize the fundamental features of the company’s proprietary Bio-Courier delivery platform:  durable RNA stabilization, non-immunogenic, efficient transfection, and no accumulation.

In-House

Our in-house pipeline is currently focused on rare Genetic Skeletal Disorders including Osteopetrosis and Achondroplasia.

Partnered

We are partnered with a leader in ophthalmic genetic disease, Avellino Labs USA, to develop the world’s first eye drop RNA interference therapy and CRISPR cas 9 gene editing cure for Corneal Dystrophy.

Are you looking to improve the stability, safety and transfection efficiency of mRNA and siRNA?

Or are you interested in our in-house programs for rare genetic skeletal disorders?

We are open to partnering.

Get in Touch

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